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The best time to visit Uganda is late December to late February, as the weather at this time of year is generally dry (though hot). A close second is the mid-June to mid-August period. Don't even think about trekking outside of these dry months.
Uganda celebrates many Christian holidays, including Christmas, Easter and Good Friday. The Muslim population honors Islamic holidays, which follow the Muslim calendar. Ramadan is the fasting month. Women's Day takes place throughout the country in early March. There are also several holidays associated with independence and events during the civil wars: NRM Anniversary Day is 26 January; Martyrs' Day is 3 June; Heroes' Day is 9 June; and Independence Day is 9 October.